Related Experiment Video
Updated: Feb 5, 2026
A Modified Method for Heterotopic Mouse Heart Transplantion
Published on: June 23, 2014
Assessment of Arterial Stiffness in Stable Heart Transplant Recipients
B Krucińska1, A Kurowski2, Ł Czyżewski3
1Student Research Circle NEFRON at the Department of Nephrology Nursing, Medical University of Warsaw, Warsaw, Poland; Department of Anesthesiology, Institute of Cardiology, Warsaw, Poland.
Insights
Arterial stiffness in heart transplant recipients is significantly impacted by age. However, immunosuppressive drugs and transplant rejection episodes do not appear to affect arterial stiffness.
Area of Science:
- Cardiology
- Transplant Medicine
- Vascular Physiology
Background:
- Arterial stiffness is influenced by genetic and environmental factors.
- Assessing arterial stiffness is crucial in post-heart transplant patients.
Purpose of the Study:
- To evaluate arterial stiffness in patients following heart transplantation.
- To identify factors associated with increased arterial stiffness in this population.
Main Methods:
- Fifty heart transplant recipients were enrolled.
- Measurements included pulse wave velocity (PWV), central systolic blood pressure (CSBP), and central diastolic blood pressure (CDBP).
- Patient medical records were analyzed.
Main Results:
- The average age of participants was 57.9 years, with 88% being male.
- Average PWV was 8.94 m/s, with an average time of 9.7 years post-transplant.
- Age (R=0.77), total cholesterol (R=0.22, P=.017), and creatinine (R=0.34) showed positive correlations with PWV.
Conclusions:
- Age is a significant determinant of arterial stiffness in heart transplant patients.
- Immunosuppressive drug type and transplant rejection episodes did not correlate with increased arterial stiffness.
Introduction:
Arterial stiffness depends on both genetic and environmental factors. The aim of this study was to assess arterial stiffness in patients after heart transplant.
Methods:
The study was conducted between May and June 2017. Fifty patients from the Transplantology Clinic of the Institute of Cardiology in Anin, Warsaw, Poland, were enrolled in the study. Pulse wave velocity (PWV), central systolic blood pressure (CSBP), and central diastolic blood pressure (CDBP) were measured and patients' medical records were also analyzed.
Results:
In the study, 50 patients aged 57.9 years on average were evaluated, of whom 88% were male patients, with average PWV of 8.94 m/s and an average time after transplant of 9.7 years. The study has shown that age (R = 0.77), total cholesterol concentration (R = 0.22, P = .017) and creatinine concentration (R = 0.34; P = .15) show positive correlation with PWV.
Conclusions:
Our data indicates that age has significant impact on arterial stiffness and the type of immunosuppressive drugs and transplant rejection episodes do not impact an increase in arterial stiffness.
Related Concept Videos
01:27Anatomy of the Heart
01:20Anatomy of the Heart
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
01:19Assessing Body Temperature - Temporal Artery
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.
Step 3: Assess the patient's...
01:15Assessment of blood pressure in brachial artery(one-step method)
Prepare for the Procedure:
01:23Assessment of blood pressure in brachial artery(two-step method)
01:07Overview of the Heart
The heart's structure...