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Updated: Feb 5, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Published on: September 10, 2018
Fabrication of folic acid decorated reductive-responsive starch-based microcapsules for targeted drug delivery via
Yuexin Sun1, Chao Shi1, Jiebing Yang2
1College of Chemistry, Jilin University, Changchun 130012, China.
Abstract:
In this present study, original, biodegradable, biocompatible, non-immunogenic and non-poisonous folic acid (FA) decorated reductive-responsive starch-based microcapsules (FA-RSMCs) were designed and fabricated via the sonochemical method for targeted delivery and controlled release of hydrophobic drugs. A green hydrophobic fluorescent dye, Coumarin 6 (C6), was encapsulated into the FA-RSMCs as a substitute of hydrophobic drugs. The as-synthesized C6-loaded FA-RSMCs were characterized by DLS, SEM and TEM. The results indicated that the obtained C6-loaded FA-RSMCs had an appropriate size range and could enter into the bloodstream with their splendid stability. Moreover, C6-loaded FA-RSMCs showed a high selectivity to Hela cells, and a brilliant targeted drugs delivery and reductive-responsive release ability for hydrophobic drugs, particularly for hydrophobic anti-cancer drugs.
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