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Updated: Feb 5, 2026

Mechanical Stimulation of Chondrocyte-agarose Hydrogels
Published on: October 27, 2012
One-step radiation synthesis of agarose/polyacrylamide double-network hydrogel with extremely excellent mechanical
Tingrui Lin1, Qingwen Bai2, Jing Peng1
1Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, The Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Abstract:
A facile one-step radiation method is first developed to synthesize agarose/polyacrylamide (AG/PAM) double-network (DN) hydrogel. Compared to other synthetic methods of DN hydrogels, our synthesis method endows the resultant AG/PAM DN hydrogel with not only top-level tensile properties with a tensile strength of 1263 ± 59 kPa and an elongation at break of 3406 ± 143%, but also highest compression properties with a compression strength of 140 ± 3 MPa and a fracture compression strain of above 99.9%. An expanding-necking phenomenon during compression process of AG/PAM DN hydrogel were observed. We propose a chain pushing-in model to interpret the energy dissipation mechanism accounting for the super-compressibility of AG/PAM DN hydrogel. This novel radiation synthesis strategy provides an insight into the development of DN hydrogels with extremely excellent mechanical properties.
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