Rapid 12-lead automated localization method: Comparison to electrocardiographic imaging (ECGI) in patient-specific...

Rapid accurate localization of the site of ventricular activation origin during catheter ablation for ventricular arrhythmias could facilitate the procedure. Electrocardiographic imaging (ECGI) using large lead sets can localize the origin of ventricular activation. We have developed an automated method to identify sites of early ventricular activation in real time using the 12-lead ECG. We aim to compare the localization accuracy of ECGI and the automated method, identifying pacing sites/VT exit based on a patient-specific model.

A patient undergoing ablation of VT on the left-ventricular endocardium and epicardium had 120-lead body-surface potential mapping (BSPM) recorded during the procedure. (1) ECGI methodology: The L1-norm regularization was employed to reconstruct epicardial potentials based on patient-specific geometry for localizing endocardial ventricular activation origin. We used the BSPM data corresponding to known endocardial pacing sites and a VT exit site identified by 3D contact mapping to analyze them offline. (2) The automatedmethod: location coordinates of pacing sites together with the time integral of the first 120 ms of the QRS complex of 3 ECG predictors (leads III, V2 and V6) were used to calculate patient-specific regression coefficients to predict the location of unknown sites of ventricular activation origin ("target" sites). Localization error was quantified over all pacing sites in millimeters by comparing the calculated location and the known reference location.

Localization was tested for 14 endocardial pacing sites and 1 epicardial VT exit site. For 14 endocardial pacing sites the mean localization error of the automated method was significantly lower than that of the ECGI (8.9 vs. 24.9 mm, p < 0.01), when 10 training pacing sites are used. Emulation of a clinical procedure demonstrated that the automated method achieved localization error of <5 mm for the VT-exit site; while the ECGI approach approximately correlates with the site of VT exit from the scar within a distance of 18.4 mm.

The automated method using only 3 ECGs shows promise to localize the origin of ventricular activation as tested by pacing, and the VT-exit site and compares favourably to inverse solution calculation, avoiding cumbersome lead sets. As 12-lead ECG data is acquired by current 3D mapping systems, it is conceivable that the algorithm could be directly incorporated into a mapping system. Further validation in a prospective cohort study is needed to confirm and extend observations reported in this study.