Studies on the structure of the human C4b-binding protein gene

Protein and cDNA sequence data have shown human C4b-binding protein to contain eight internally homologous repeat units, each approx. 61 amino acids in length. Repeat units conforming to the same consensus sequence have been found in other complement and non-complement proteins. Southern blot analysis together with isolation, characterisation and sequencing of genomic clones has allowed the study of intron/exon organisation in the human C4b-binding protein gene and the identification of a Bg/II restriction fragment length polymorphism.