Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Research Domains
  1. Home
  3. Research Domains

Related Concept Videos

Pancreatic Juice and Secretion01:26

Pancreatic Juice and Secretion

3.0K
Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
3.0K
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.3K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.3K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

745
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
745
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

373
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
373
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

877
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
877
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.6K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.6K
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Precancerous Neoplastic Cells Can Move Through The Pancreatic Ductal System.
  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Precancerous Neoplastic Cells Can Move Through The Pancreatic Ductal System.

    • Related Experiment Video

    Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
    06:24

    Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

    Published on: April 11, 2025

    940

    Precancerous neoplastic cells can move through the pancreatic ductal system.

    Alvin P Makohon-Moore1, Karen Matsukuma2, Ming Zhang3

    • 1The David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

    Nature
    |September 5, 2018

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    Pancreatic cancer progression involves precursor lesions evolving over years. Genetic analysis reveals distinct lesions in one pancreas often stem from a single tumor colonizing the ductal system.

    More Related Videos

    Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
    07:08

    Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

    Published on: February 2, 2024

    1.5K
    Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
    06:21

    Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

    Published on: November 19, 2019

    12.2K

    Related Experiment Videos

    Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
    06:24

    Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

    Published on: April 11, 2025

    940
    Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
    07:08

    Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets

    Published on: February 2, 2024

    1.5K
    Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
    06:21

    Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma

    Published on: November 19, 2019

    12.2K

    Area of Science:

    • Oncology
    • Genetics
    • Evolutionary Biology

    Background:

    • Most adult carcinomas arise from noninvasive precursor lesions.
    • The evolutionary and genetic links between co-existing lesions remain poorly understood.

    Purpose of the Study:

    • To investigate the evolutionary and genetic relationships among pancreatic cancer and its precursor lesions within the same pancreas.
    • To reframe the step-wise progression model of pancreatic cancer.

    Main Methods:

    • Analysis of somatic variants in pancreatic cancers and precursor lesions from distinct pancreatic regions.
    • Inference of evolutionary relationships between lesions.

    Main Results:

    • Identified that an ancestral cell initiated and expanded clonally, forming multiple lesions.
    • Subsequent driver gene mutations led to invasive pancreatic cancer over many years.
    • Distinct, high-grade precursor lesions in a single pancreas often represent a single neoplasm that has colonized the ductal system.

    Conclusions:

    • Pancreatic cancer develops through a multi-step progression over an extended period.
    • Independent precursor lesions within a single pancreas can originate from a common neoplastic source.
    • This study reframes the understanding of pancreatic cancer evolution and spatial-genetic divergence.