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Related Concept Videos

Non-ohmic Devices00:51

Non-ohmic Devices

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In most substances, the current flow is proportional to the voltage applied to it. A simple relationship between the values of current, voltage, and resistance is known as Ohm's law. Nonohmic devices do not exhibit a linear relationship between voltage and current. One such device is the semiconducting circuit element known as a diode. A diode is a circuit device that allows current flow in only one direction.
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Mnemonic Devices01:23

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Mnemonic devices are cognitive tools that facilitate memory retention by linking new information to familiar patterns or organizational strategies. These techniques are beneficial for remembering complex or lengthy sets of information by simplifying and structuring them in easily retrievable ways.
Acronyms
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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Load along a Single Axis01:29

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In structural engineering, the analysis of beams subjected to varying loads is a critical aspect of understanding the behavior and performance of these structural elements. A common scenario involves a beam subjected to a combination of different load distributions.
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Single Pipe Systems01:24

Single Pipe Systems

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In pipe flow analysis, problems are typically categorized into three types — Type I, Type II, and Type III — based on the known parameters and the desired outcome. Each type of problem addresses specific engineering requirements using fluid properties, pipe characteristics, and operational conditions.
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Angular Momentum: Single Particle01:10

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Angular momentum is directed perpendicular to the plane of the rotation, and its magnitude depends on the choice of the origin. The perpendicular vector joining the linear momentum vector of an object to the origin is called the “lever arm.” If the lever arm and linear momentum are collinear, then the magnitude of the angular momentum is zero. Therefore, in this case, the object rotates about the origin such that it lies on the rim of the circumference defined by the lever arm...
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Cell Capture Using a Microfluidic Device
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Cell Capture Using a Microfluidic Device

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Single-cell assay on microfluidic devices.

Qiushi Huang1, Sifeng Mao, Mashooq Khan

  • 1Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China. jmlin@mail.tsinghua.edu.cn.

The Analyst
|September 5, 2018
PubMed
Summary
This summary is machine-generated.

Microfluidic technologies enable the study of single-cell heterogeneity for disease identification and personalized medicine. This review details microfluidic methods for single-cell isolation, lysis, and analysis, discussing current techniques and their trade-offs.

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Area of Science:

  • Biotechnology
  • Cell Biology
  • Medical Diagnostics

Background:

  • Single-cell analysis is crucial for understanding cellular heterogeneity.
  • This heterogeneity plays a key role in disease progression and treatment response.
  • Personalized medicine requires detailed insights into individual cell behavior.

Purpose of the Study:

  • To provide a comprehensive overview of microfluidic approaches for single-cell analysis.
  • To discuss techniques for single-cell isolation, lysis, and downstream analysis.
  • To evaluate the advantages and disadvantages of current microfluidic methods.

Main Methods:

  • Review of various microfluidic platforms and techniques.
  • Detailed discussion of methods for single-cell isolation.
  • Exploration of microfluidic strategies for cell lysis and subsequent analysis.

Main Results:

  • Microfluidics offers diverse functionalities for single-cell studies.
  • Key techniques in single-cell isolation, lysis, and analysis are presented.
  • Comparative analysis of the pros and cons of different microfluidic approaches.

Conclusions:

  • Microfluidic technologies are advancing the field of single-cell analysis.
  • These methods are vital for disease biomarker discovery and personalized therapeutic strategies.
  • The review provides a valuable resource for researchers in the field.