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Related Concept Videos

Autophagy01:27

Autophagy

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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
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Potential Energy00:52

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The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
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A conservative force, such as a gravitational or elastic force, gives the body the capacity to do work. This capacity, measured as the potential energy, depends on the body's location or “position” relative to a fixed reference position or datum. The gravitational potential energy is considered zero at the reference point. Suppose a body is located at some vertical distance above a fixed horizontal reference or datum. In that case, the weight of the body has positive gravitational potential...
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On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
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Cell Potential and Free Energy02:58

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Thermodynamics of a Redox Reaction
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siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
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Triptolide, A Potential Autophagy Modulator.

Yan-Ming Wei1, Yong-Hui Wang2, Hui-Qing Xue2

  • 1Experimental Management Centre, Shanxi University of Chinese Medicine, Jinzhong, Shanxi Province, 030619, China. weiyanming2005@aliyun.com.

Chinese Journal of Integrative Medicine
|September 5, 2018
PubMed
Summary
This summary is machine-generated.

Triptolide, a compound from Tripterygium wilfordii, modulates autophagy, influencing its therapeutic potential in diseases. This review explores triptolide

Keywords:
Tripterygium wilfordii Hook Fapoptosisautophagytriptolide

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Area of Science:

  • Pharmacology and molecular biology, focusing on cellular processes.

Background:

  • Triptolide is a key compound from Tripterygium wilfordii Hook F with diverse pharmacological actions.
  • Autophagy, a cellular degradation process, is implicated in various human diseases when dysfunctional.
  • Modulation of autophagy by triptolide has been linked to its neuroprotective, anti-tumor, and organ-protective effects.

Purpose of the Study:

  • To review current knowledge on how triptolide influences autophagy.
  • To analyze the molecular pathways involved in triptolide-modulated autophagy.
  • To explore the interplay between autophagy and apoptosis under triptolide treatment.

Main Methods:

  • Literature review of studies investigating triptolide and autophagy.
  • Analysis of molecular mechanisms and signaling pathways.
  • Examination of the relationship between autophagy and apoptosis.

Main Results:

  • Triptolide's effects on neuroprotection, anti-tumor activity, and organ toxicity are mediated through autophagy modulation.
  • Specific pathways involved in triptolide-induced autophagy are identified.
  • Cross-talk between autophagy and apoptosis pathways influenced by triptolide is observed.

Conclusions:

  • Autophagy plays a crucial role in the pharmacological effects of triptolide.
  • Understanding triptolide-modulated autophagy offers insights into its therapeutic applications.
  • Triptolide shows potential as a novel autophagy modulator for treating various diseases.