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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Related Experiment Video

Updated: Feb 5, 2026

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Epigenetics in Hematological Malignancies.

Nataly Cruz-Rodriguez1,2,3, Alba L Combita1,2, Jovanny Zabaleta4,5,6

  • 1Programa de Investigación e Innovación en Leucemias Agudas y Crónicas (PILAC), Instituto Nacional de Cancerología, Bogotá, Colombia.

Methods in Molecular Biology (Clifton, N.J.)
|September 5, 2018
PubMed
Summary

Epigenetic alterations in acute leukemia disrupt gene regulation, driving cancer development. Understanding these changes offers new therapeutic targets for precision medicine.

Keywords:
Acute leukemiaEpigeneticsHematopoiesisRegulation

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Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Acute leukemias are aggressive blood cancers, particularly in adults.
  • Advances in gene sequencing reveal complex genetic landscapes in these diseases.

Purpose of the Study:

  • To review epigenetic alterations in acute leukemia.
  • To explore their mechanisms, prognostic value, and therapeutic potential.

Main Methods:

  • Review of current literature on epigenetic regulators in acute leukemia.
  • Analysis of gene expression and sequencing data.
  • Examination of epigenetic mechanisms impacting leukemogenesis.

Main Results:

  • Epigenetic alterations significantly impact cellular biology without DNA sequence changes.
  • These alterations disrupt gene activation/repression balance, leading to aberrant gene expression.
  • Epigenetic changes are crucial in acute leukemia pathogenesis and maintenance.

Conclusions:

  • Epigenetic modifications are key drivers in acute leukemia.
  • Targeting epigenetic regulators presents promising avenues for precision medicine in leukemia treatment.