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Related Concept Videos

Teeth01:15

Teeth

1.8K
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
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Tooth Anatomy01:21

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
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Understanding Self-Concept01:20

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The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...
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Understanding Deception01:14

Understanding Deception

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Deception is a pervasive aspect of human communication. Empirical studies have shown that most individuals engage in some form of deceit on a daily basis, with approximately 20% of social exchanges involving deceptive elements. Lying follows a developmental trajectory, peaking during adolescence and declining with age, possibly due to the maturation of cognitive control and social accountability.Cognitive and Social Factors in Deception DetectionDespite its prevalence, accurately detecting...
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Related Experiment Video

Updated: Feb 5, 2026

The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
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The Slice Culture Method for Following Development of Tooth Germs In Explant Culture

Published on: November 13, 2013

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From understanding tooth development to bioengineering of teeth.

Irma Thesleff1

  • 1Developmental Biology Research Program, Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

European Journal of Oral Sciences
|September 5, 2018
PubMed
Summary

Recent advances in developmental and stem cell biology offer hope for growing new teeth. Research shows that manipulating signaling pathways can induce tooth formation, paving the way for future dental bioengineering.

Keywords:
hypodontiasignaling moleculestem cellstissue interactionstooth regeneration

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Related Experiment Videos

Last Updated: Feb 5, 2026

The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
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14.6K
Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Bioengineering

Background:

  • Significant progress in understanding tooth development and stem cell programming over the last 15 years.
  • Knowledge of signaling molecules and genes regulating tooth development has advanced considerably.
  • The 2006 breakthrough in stem cell biology allows patient cells to be reprogrammed into pluripotent stem cells.

Purpose of the Study:

  • To explore the possibilities of growing new teeth and tooth bioengineering.
  • To investigate the potential of programming stem and progenitor cells into tooth-specific cell types.
  • To assess the feasibility of future clinical applications for regenerative dentistry.

Main Methods:

  • Utilizing transgenic mouse models to study tooth development.
  • Investigating signaling networks that govern early tooth development.
  • Research focused on programming stem cells for tissue regeneration.

Main Results:

  • Demonstrated induction of new tooth formation by manipulating signaling networks in mouse models.
  • Established that patient-derived cells can be reprogrammed into pluripotent stem cells.
  • Active global research is ongoing to program stem cells for tooth development.

Conclusions:

  • Progress in developmental and stem cell biology fuels optimism for growing new teeth.
  • Tooth bioengineering holds promise for future dental treatments.
  • Regenerative approaches may revolutionize dental care in the near future.