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The association between mean platelet volume levels and poststroke depression.
Huihua Qiu1, Yuntao Liu1, Hongfei He1
1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Brain and Behavior
|September 5, 2018
Summary
Elevated mean platelet volume (MPV) levels in stroke patients may predict post-stroke depression (PSD). Higher MPV at admission correlated with PSD development one month later.
Area of Science:
- Neurology
- Hematology
- Psychiatry
Background:
- Previous studies linked high mean platelet volume (MPV) to depression.
- Post-stroke depression (PSD) is a common complication following ischemic stroke.
Purpose of the Study:
- To investigate the association between MPV and the incidence of PSD.
- To determine if MPV can serve as a predictor for PSD.
Main Methods:
- 185 patients with acute ischemic stroke were analyzed.
- Peripheral venous blood samples were collected at admission to measure MPV.
- PSD was diagnosed using the HAMD-17 score (score >7).
Main Results:
- 32.4% of patients developed PSD.
- PSD patients exhibited significantly higher MPV levels (9.3 ± 1.8 fl) compared to non-PSD patients (8.5 ± 1.6 fl).
- High MPV levels (≥9.1 fl) were independently correlated with PSD (OR 2.762, p=0.025).
Conclusions:
- Higher MPV levels at admission are associated with the development of PSD.
- MPV may serve as a potential predictive biomarker for PSD in stroke patients.
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