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Updated: Feb 5, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
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Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

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HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors

Toru Usui1, Arun Tailor1, Lee Faulkner1

  • 1MRC Center for Drug Safety Science, Department of Molecular and Clinical Pharmacology , University of Liverpool , Sherrington Building, Ashton Street , Liverpool , L69 3GE , England.

Chemical Research in Toxicology
|September 5, 2018
PubMed

The HLA class I allele HLA-A*33:03 is a risk factor for ticlopidine-induced liver injury. Herein, we show HLA class I-restricted ticlopidine-specific CD8+ T-cell activation in healthy donors expressing HLA-A*33:03. Cloned CD8+ T-cells proliferated and secreted IFN-γ in the presence of ticlopidine and autologous antigen presenting cells. A reduction of the T-cell response after blocking with HLA-class I and HLA-A*33 antibodies indicates that the interaction between drugs and the HLA allele detected in genetic association studies may be important for T-cell activation.

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