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Subclinical right ventricular dysfunction in intermittent and persistent mildly asthmatic children on tissue Doppler

Cem Ozde1, Mahmut Dogru2, Şükriye Ozde3

  • 1Department of Cardiology, Düzce University Faculty of Medicine, Düzce, Turkey.

Pediatrics International : Official Journal of the Japan Pediatric Society
|September 5, 2018
PubMed

Insights

Serum NT-proBNP levels are elevated in children with asthma, indicating subclinical right ventricular dysfunction. This finding suggests NT-proBNP can serve as an early biomarker for detecting cardiac changes in pediatric asthma patients.

Area of Science:

  • Pediatric Cardiology
  • Respiratory Medicine
  • Biomarker Discovery

Background:

  • Bronchial asthma can lead to pulmonary hypertension and right ventricular (RV) dysfunction.
  • Early detection of subclinical RV dysfunction is crucial for managing pediatric asthma.
  • Elevated RV afterload in asthma patients can precipitate cor pulmonale later in life.

Purpose of the Study:

  • To investigate serum NT-proBNP as a biomarker for subclinical RV dysfunction in children with asthma.
  • To assess RV function using echocardiography in pediatric asthma patients.
  • To correlate NT-proBNP levels with echocardiographic findings of RV dysfunction.

Main Methods:

  • Enrolled 68 pediatric asthma patients and 69 healthy controls.
  • Conducted 2D and tissue-Doppler echocardiography to evaluate RV function.
  • Measured pulmonary function via spirometry and serum NT-proBNP concentrations.

Main Results:

  • Asthma patients showed significantly decreased RV diastolic function (E'/A' ratio).
  • RV myocardial performance index was significantly higher in the asthma group.
  • Serum NT-proBNP concentrations were significantly elevated in children with asthma compared to controls.

Conclusions:

  • Elevated serum NT-proBNP is linked to subclinical RV dysfunction in pediatric asthma.
  • Echocardiographic assessment reveals significant RV functional impact in children with asthma.
  • NT-proBNP may serve as a valuable biomarker for early RV dysfunction detection in pediatric asthma.
Abstract

Keywords:
N-terminal pro-B-type natriuretic peptideasthmachildrensubclinical right ventricular dysfunction

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