Related Experiment Video
Updated: Feb 5, 2026
14:14
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
Published on: August 12, 2018
9.4K
Lead-DBS v2: Towards a comprehensive pipeline for deep brain stimulation imaging
Andreas Horn1, Ningfei Li1, Till A Dembek2
1Movement Disorders & Neuromodulation Unit, Department for Neurology, Charité - University Medicine Berlin, Germany.
Neuroimage
|September 5, 2018
Summary
Lead-DBS software provides updated pipelines for deep brain stimulation (DBS) imaging and connectomics. This open-source tool facilitates precise electrode placement and analysis for movement disorders and other conditions.
Area of Science:
- Neuroimaging and Computational Neuroscience
- Medical Engineering and Technology
Background:
- Deep brain stimulation (DBS) is a crucial treatment for movement disorders, demanding precise electrode placement for optimal outcomes.
- Accurate reconstruction of electrode placement is vital for analyzing the relationship between location and clinical results, presenting neuroimaging challenges.
- The open-source Lead-DBS toolbox, available since 2014, has become a popular platform for DBS imaging, continuously updated by a global research community.
Purpose of the Study:
- To present updated deep brain stimulation (DBS) and connectome analysis pipelines within the Lead-DBS software.
- To demonstrate the utility of these revised pipelines using both high-field and clinical-setting imaging data.
- To provide a comprehensive, open-source resource for DBS imaging and connectomics research.
Main Methods:
- Co-registration and nonlinear warping of neuroimaging data using multiple algorithms and approaches.
- Reconstruction of DBS electrodes using various methods, followed by calculation of the volume of tissue activated (VTA).
- Application of whole-brain tractography algorithms to estimate structural and functional connectivity from diffusion MRI data.
Main Results:
- Demonstration of updated Lead-DBS pipelines on single-patient and retrospective cohort data.
- Comparative analysis of different neuroimaging registration, electrode reconstruction, VTA modeling, and tractography methods.
- Evaluation of preprocessing strategy impact on predicting clinical improvement in Parkinson's disease (PD) patients.
Conclusions:
- The updated Lead-DBS pipelines offer a comprehensive, open-source solution for advanced DBS imaging and connectomics.
- These tools facilitate precise electrode localization and detailed analysis of stimulation effects and brain connectivity.
- The collaborative development empowers current and future research in DBS applications and related neurological conditions.
Related Concept Videos
01:14Brain Imaging
747
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
747
01:22Phase-lead and Phase-lag Controllers
552
Understanding the working function of different types of controllers can be illustrated with practical analogies, such as adjusting a stereo's volume equalizer. Cranking up the bass involves a phase-lead controller, which functions as a high-pass filter, while increasing the treble uses a phase-lag controller, which acts as a low-pass filter. PD controllers, similar to high-pass filters, enhance the system's response to high-frequency components. PI controllers, akin to low-pass...
552
01:29Stimulants
1.0K
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
1.0K
01:24Time and frequency -Domain Interpretation of Phase-lead Control
456
Phase-lead controllers are commonly used in various control systems to enhance response speed and stability. Adjusting the brightness on a television screen offers a practical example of phase-lead control. When contrast is enhanced, a phase-lead controller is employed. Mathematically, phase-lead control is identified when the first parameter is smaller than the second.
The design of phase-lead control involves the strategic placement of poles and zeros to balance steady-state error and system...
The design of phase-lead control involves the strategic placement of poles and zeros to balance steady-state error and system...
456
01:20Motor Unit Stimulation
3.8K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
3.8K
01:22Muscle Stimulation Frequency
4.6K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
4.6K