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Related Concept Videos

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Related Experiment Video

Updated: Feb 5, 2026

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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Seizures after transplantation.

Peijia Lin1, Xin Tian1, Xuefeng Wang2

  • 1Department of Neurology, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Chongqing 400016, China.

Seizure
|September 5, 2018
PubMed
Summary

Seizures are a common complication after transplantation, with varying incidence rates. While many patients have a good prognosis, further research is needed on causes and treatments for transplant recipients experiencing seizures.

Keywords:
Clinical characterEpilepsyImmunosuppressantSeizureTransplantationTreatment

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Area of Science:

  • Neurology
  • Transplantation Medicine
  • Clinical Research

Background:

  • Central nervous system complications, including seizures, are frequently observed in transplant recipients.
  • The incidence and clinical presentation of seizures vary significantly across different transplantation types.

Purpose of the Study:

  • To review the history, incidence, clinical manifestations, optimal treatment, and prognosis of seizures in patients who have undergone transplantation.
  • To consolidate current knowledge on post-transplant seizures for clinical and research purposes.

Main Methods:

  • A comprehensive literature search was conducted on PubMed in October 2017.
  • Search terms included combinations of "transplantation" and "seizure", "epilepsy", or "status epilepticus", as well as "immunosuppressant" and "seizure" or "epilepsy".
  • Only original research publications were included, excluding articles not based on new data.

Main Results:

  • Seizures, encompassing generalized, focal, and status epilepticus, are a notable complication post-transplantation.
  • Incidence rates for seizures ranged from 7%-27% in solid organ transplantations and 1.6%-15.4% in hematopoietic stem cell transplantation.
  • Seizures predominantly occurred early in the post-transplantation period, with most patients experiencing a favorable prognosis, though recurrent or intractable cases were noted.

Conclusions:

  • The precise pathogenesis of new-onset seizures or epilepsy in transplant recipients requires further investigation.
  • Prospective studies and research focused on developing effective therapeutic strategies for post-transplant seizures are essential.