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Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group Therapy01:26

Group Therapy

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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Behavior Therapy01:22

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Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
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Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
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Updated: Feb 5, 2026

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
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Combination therapy in cachexia.

Egidio Del Fabbro1

  • 1Virginia Commonwealth University, Richmond, VA, USA. egidio.delfabbro@vcuhealth.org.

Annals of Palliative Medicine
|September 6, 2018
PubMed
Summary

Treating cancer cachexia requires a multi-faceted approach targeting its complex causes. Combining therapies simultaneously offers a promising strategy for improving patient outcomes in this syndrome.

Area of Science:

  • Oncology
  • Metabolic Medicine
  • Clinical Therapeutics

Background:

  • Cancer cachexia is a complex, multifactorial syndrome characterized by weight loss, anorexia, and inflammation.
  • Previous therapeutic strategies often focused on single aspects of cachexia, yielding limited success.
  • A comprehensive approach is needed to address the diverse pathophysiological mechanisms involved.

Purpose of the Study:

  • To explore the rationale for multi-faceted treatment strategies in cancer cachexia.
  • To evaluate the feasibility and clinical outcomes of combined therapeutic interventions.
  • To identify key components of effective multimodal regimens for managing cancer cachexia.

Main Methods:

  • Review of existing literature on cancer cachexia interventions.
Keywords:
Multimodal therapycachexiacancer

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  • Analysis of preliminary trials combining pharmacological and non-pharmacological therapies.
  • Examination of therapeutic regimens targeting multiple pathophysiological pathways.

    • Main Results:

    • Multimodal therapy combining pharmacological and non-pharmacological interventions is feasible.
    • Combined approaches have shown potential for improving selected clinical outcomes in cancer cachexia.
    • Successful regimens often target major cachexia mechanisms simultaneously and include supportive care.

    Conclusions:

    • A comprehensive, multi-faceted treatment approach is essential for effectively managing cancer cachexia.
    • Simultaneous modulation of key pathophysiological mechanisms, alongside supportive care, represents a promising therapeutic direction.
    • Early patient identification and tailored multimodal interventions are crucial for optimizing outcomes.