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Multicentric reticulohistiocytosis: a case report.
Azadèh Farokhi1, Richard M van Vugt2, Rick Hoekzema3
1VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. a.farokhi@vumc.nl.
BMC Research Notes
|September 6, 2018
Summary
Multicentric reticulohistiocytosis (MRH), a rare histiocytosis, presents with skin lesions and joint pain. This case highlights the importance of repeat biopsies for accurate MRH diagnosis when initial results are inconclusive.
Area of Science:
- Rheumatology
- Dermatology
- Pathology
Background:
- Multicentric reticulohistiocytosis (MRH) is a rare non-Langerhans cell histiocytosis.
- Characterized by skin manifestations and severe erosive arthritis.
- Diagnosis is confirmed by characteristic histopathological findings.
Observation:
- A case report of a newly diagnosed MRH in a 26-year-old female.
- Initial symptoms included papules, nodules on hands, and polyarticular pain.
- Radiographs revealed significant erosions in small hand and foot joints.
Findings:
- Initial biopsies showed non-specific histological findings.
- Subsequent biopsies confirmed the diagnosis of MRH.
- Clinical presentation was key in guiding further diagnostic steps.
Implications:
- This case underscores the diagnostic challenges in MRH.
- Emphasizes the critical role of repeat biopsies for definitive diagnosis.
- Highlights the need to correlate clinical and histological findings in rare diseases.
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