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Graves' disease in children.

Juliane Léger1, Isabelle Oliver2, Danielle Rodrigue3

  • 1Department of Pediatric Endocrinology and Diabetology and Reference Center for rare Diseases of Growth and Development, CHU Robert-Debre, 75019 Paris, France.

Annales D'Endocrinologie
|September 6, 2018
PubMed
Summary

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This summary is machine-generated.

Graves' disease diagnosis in children relies on suppressed TSH and TSH receptor antibodies, with drug therapy as the primary treatment. Medical care by pediatric endocrinology specialists is crucial for effective management and potential long-term outcomes.

Area of Science:

  • Pediatric Endocrinology
  • Autoimmune Disorders
  • Thyroidology

Background:

  • Graves' disease is an autoimmune condition causing hyperthyroidism in children.
  • Accurate diagnosis and management are essential for preventing complications.

Purpose of the Study:

  • To outline diagnostic criteria for Graves' disease in children.
  • To detail current therapeutic strategies and management guidelines.
  • To emphasize the importance of specialized pediatric care.

Main Methods:

  • Diagnosis relies on suppressed serum TSH concentrations and anti-TSH receptor antibodies.
  • Thyroid ultrasound and scintigraphy are not primary diagnostic tools.
  • Assessment of T4L and T3L levels aids in management and prognosis.
Keywords:
AdolescentCarbimazoleChildChirurgieEnfantGraves’ diseaseHyperthyroidismHyperthyroïdieIode radioactifLong termLong termeMaladie de basedowPrognosisPronosticRadioactive iodine treatmentSurgeryThiamazole

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Main Results:

  • Antithyroid drug therapy (imidazole, carbimazole, thiamazole) is the primary treatment; propylthiouracil is contraindicated.
  • Monitoring for neutropenia and liver function is important before and during treatment.
  • Medical treatment has a 50% remission rate, with radical options available.

Conclusions:

  • Graves' disease in children requires specialized pediatric endocrinologist care.
  • Treatment duration is typically 3-6 years, with potential need for radical interventions.
  • Special considerations are necessary for pregnancy planning in affected females.