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A Radiologist's Guide to Response Evaluation Criteria in Solid Tumors.
Usha R Lalchandani1, Vaibhav Sahai2, Katherine Hersberger2
1Tumor Response Assessment Core (TRAC), Rogel Cancer Center, University of Michigan Health System-Michigan Medicine, Ann Arbor, MI, 48109.
Current Problems in Diagnostic Radiology
|September 6, 2018
Summary
Response Evaluation Criteria in Solid Tumors (RECIST) are standard for chemotherapy. Immune-related RECIST emerged with immunotherapy, requiring radiologists to understand imaging criteria for accurate tumor assessment and patient management.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Response Evaluation Criteria in Solid Tumors (RECIST) versions 1.0 and 1.1 are established standards for assessing conventional chemotherapy response.
- The rise of immunotherapy necessitates specialized criteria, leading to the development of immune-related RECIST (irRECIST).
- Accurate tumor response assessment via imaging is vital for patient management and clinical trial efficacy.
Purpose of the Study:
- To provide a comprehensive review of published RECIST criteria.
- To highlight the importance of understanding different response criteria for radiologists.
- To emphasize the role of imaging in assessing tumor response to various therapies.
Main Methods:
- Systematic review of published RECIST criteria, including standard and immune-related versions.
- Analysis of the role of medical imaging in tumor response assessment.
- Discussion of the practical application of RECIST criteria for radiologists.
Main Results:
- RECIST criteria are universally accepted for conventional chemotherapy response evaluation.
- Immune-related RECIST have been developed to address the unique response patterns seen with immunotherapy.
- Radiologists require familiarity with diverse RECIST criteria for precise lesion identification, measurement, and response assessment.
Conclusions:
- Understanding RECIST and irRECIST is crucial for radiologists in modern oncology.
- Standardized imaging assessment criteria optimize patient management and clinical trial outcomes.
- This review serves as a guide to published RECIST criteria for clinical practice.