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Pulse wave analyzed cardiovascular parameters in young first degree relatives of hypertensives

Jayesh Dalpatbhai Solanki1, Hemant B Mehta1, Chinmay J Shah1

  • 1Department of Physiology, Government Medical College, Bhavnagar, Gujarat, India.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences
|September 6, 2018
PubMed

Insights

First-degree relatives of hypertensive individuals show early signs of cardiovascular aging. Pulse wave analysis (PWA) reveals increased vascular stiffness and central blood pressure, indicating a need for early prevention strategies.

Area of Science:

  • Cardiovascular Physiology
  • Hypertension Research
  • Preventive Cardiology

Background:

  • First-degree relatives (FDRs) of hypertensive individuals are predisposed to hypertension (HTN).
  • Hypertension accelerates cardiovascular aging.
  • Pulse wave analysis (PWA) noninvasively assesses central hemodynamics and vascular stiffness.

Purpose of the Study:

  • To investigate PWA-derived cardiovascular parameters in FDRs of hypertensive individuals compared to controls.
  • To identify early signs of cardiovascular aging in FDRs of hypertensive individuals.

Main Methods:

  • A case-control study involving 119 FDRs of hypertensive individuals and 119 matched controls.
  • Oscillometric PWA performed using Mobil-o-Graph (IEM, Germany).
  • Comparison of cardiovascular parameters including central blood pressure (cBP), stroke work (SW), pulse wave velocity (PWV), and augmentation index at HR 75 (AIx@75).

Main Results:

  • FDRs exhibited significantly higher brachial and central blood pressures, SW, rate pressure product, PWV, and AIx@75 compared to controls.
  • Study variables correlated more strongly with brachial blood pressure than age or anthropometrics.
  • No significant difference in PWA results between maternal and paternal inheritance.

Conclusions:

  • PWA identifies early cardiovascular aging in young FDRs of hypertensive individuals.
  • Findings suggest a need for primary prevention and further research.
  • Early detection via PWA may predict future cardiovascular disease, including hypertension.
Abstract

Keywords:
Cardiovascularfirst degree relativehypertensiveoscillometricpulse wave analysis

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