Related Experiment Video

Updated: Feb 5, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

10.9K

Activation of viral defense signaling in cancer

Maria Gonzalez-Cao1, Niki Karachaliou2, Mariacarmela Santarpia3

  • 1Rosell Oncology Institute (IOR), Dexeus University Hospital, Quironsalud Group, C/ Sabino Arana, 5, Barcelona 08028, Spain.

Therapeutic Advances in Medical Oncology
|September 6, 2018
PubMed

Insights

Harnessing innate immunity can enhance cancer therapies. Engaging both innate and adaptive immune responses improves tumor treatment and response to immune checkpoint inhibitors.

Area of Science:

  • Immunology
  • Oncology
  • Cancer Therapy

Background:

  • Immune responses, both innate and adaptive, are crucial for fighting infections.
  • Cancer therapies are increasingly leveraging the immune system for treatment.
  • Engaging both innate and adaptive immunity is beneficial for effective cancer therapy.

Purpose of the Study:

  • To review the role of innate immunity in cancer therapy.
  • To explore how innate immunity can prime tumors for enhanced response to immune checkpoint inhibitors.
  • To provide an overview of compounds in development and ongoing clinical trials.

Main Methods:

  • Review of current knowledge on innate immunity.
  • Analysis of strategies to utilize innate immunity in cancer treatment.
  • Discussion of clinical trials and compounds in development.

Main Results:

  • Innate immunity plays a critical role in initiating and shaping adaptive immune responses relevant to cancer.
  • Priming tumors with innate immune stimuli can improve their susceptibility to immune checkpoint inhibitors.
  • Several compounds and strategies targeting innate immunity are under investigation.

Conclusions:

  • Coordinated innate and adaptive immune responses are essential for effective cancer immunotherapy.
  • Targeting innate immunity offers a promising strategy to enhance the efficacy of immune checkpoint inhibitors.
  • Further research and clinical trials are needed to fully realize the potential of innate immune-based cancer therapies.
Keywords:
TLRscancer immunotherapyinnate immunityviral defense signaling

More Related Videos

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

3.3K
A High-throughput Cre-Lox Activated Viral Membrane Fusion Assay to Identify Inhibitors of HIV-1 Viral Membrane Fusion07:22

A High-throughput Cre-Lox Activated Viral Membrane Fusion Assay to Identify Inhibitors of HIV-1 Viral Membrane Fusion

Published on: August 14, 2018

7.0K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.8K
Defenses Against Pathogens and Herbivores02:26

Defenses Against Pathogens and Herbivores

Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
29.6K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
2.8K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
9.7K
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.2K
Viral Structure00:56

Viral Structure

Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.6K