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Diabetic nephropathy: newer therapeutic perspectives
Krishna C Keri1, Naga S Samji2, Samuel Blumenthal1
1Department of Medicine, Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI, USA.
Journal of Community Hospital Internal Medicine Perspectives
|September 6, 2018
Summary
Diabetic nephropathy (DN) is a major cause of kidney failure. New drug targets beyond traditional methods show promise in clinical trials for managing DN and its complications.
Area of Science:
- Nephrology
- Endocrinology
- Pharmacology
Background:
- Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD), contributing to significant morbidity and mortality.
- DN exacerbates cardiovascular risk, highlighting the need for comprehensive management strategies.
Purpose of the Study:
- To review novel pharmacological targets and emerging drugs for diabetic nephropathy.
- To discuss the clinical relevance of recent research in managing DN.
Main Methods:
- Review of recent scientific literature and clinical trial data.
- Analysis of pathways including SGLT-2 inhibition, AGE-RAGE, ASK-1, and endothelin pathways.
Main Results:
- Sodium glucose co-transporter type 2 (SGLT-2) inhibitors demonstrate favorable outcomes.
- Novel pathways targeting inflammation, oxidative stress, and specific molecular mechanisms are under investigation.
Conclusions:
- Emerging drugs targeting novel pathways show potential for DN treatment.
- Ongoing research will guide future clinical use of new therapies for diabetic nephropathy.
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