Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

2.9K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.9K
Microorganisms in Agriculture and Food industry01:27

Microorganisms in Agriculture and Food industry

1.5K
Microorganisms play a crucial role in agriculture and the food industry, contributing to soil fertility, crop protection, and food production. Their functions range from nitrogen fixation and biopesticide production to fermentation and food preservation, making them indispensable to sustainable farming and food safety.Role in AgricultureNitrogen-fixing bacteria, such as Rhizobium (symbiotic) and Azotobacter (free-living), convert atmospheric nitrogen into ammonia through biological nitrogen...
1.5K
Typical Model Studies01:30

Typical Model Studies

637
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
637
Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs01:20

Bioequivalence Experimental Study Designs: Completely Randomized and Randomized Block Designs

250
Body:Bioequivalence experimental study designs are crucial methodologies used in evaluating and comparing the bioavailability of different drug products. These designs are categorized into various types: completely randomized, randomized block, repeated measures, cross and carry-over, and Latin square designs.Completely randomized designs involve randomly allocating treatments to all subjects participating in the experiment. This allocation is achieved by assigning unique random numbers to...
250
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Experimental Determination of Chemical Formula02:37

Experimental Determination of Chemical Formula

47.4K
The elemental makeup of a compound defines its chemical identity, and chemical formulas are the most concise way of representing this elemental makeup. When a compound’s formula is unknown, measuring the mass of its constituent elements is often the first step in determining the formula experimentally.
47.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IgG:FcγRIIb Signaling on Mast Cells Blocks Allergic Airway Inflammation.

International journal of molecular sciences·2025
Same author

Multidimensional third-generation sequencing of modified DNA bases allows interrogation of complex biological systems.

Nature communications·2025
Same author

T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice.

Mucosal immunology·2025
Same author

Allergen-specific IgA and IgG antibodies as inhibitors of mast cell function in food allergy.

Frontiers in allergy·2024
Same author

IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.

Frontiers in immunology·2024
Same author

IgG:FcγRIIb signals block effector programs of IgE:FcεRI-activated mast cells but spare survival pathways.

The Journal of allergy and clinical immunology·2023

Related Experiment Video

Updated: Feb 5, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

26.6K

Experimental Models for Studying Food Allergy.

Cynthia Kanagaratham1, Benjamin F Sallis1, Edda Fiebiger1

  • 1Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Cellular and Molecular Gastroenterology and Hepatology
|September 6, 2018
PubMed
Summary
This summary is machine-generated.

Food allergy is a growing global health issue. This review examines mouse models for food allergy research, comparing their relevance to human conditions to improve new therapy development.

Keywords:
Allergen ChallengeAllergen SensitizationAnaphylaxisEPIT, epicutaneous immunotherapyEpictutaneous SensitizationFCER1A, high-affinity immunoglobulin epsilon receptor subunit alphaFCERIAFcεRI, high-affinity immunoglobulin E receptorGM-CSF, granulocyte-macrophage colony-stimulating factorHSC, hematopoietic stem cellHumanized ModelIL, interleukinIg, immunoglobulinIgELCT, long chain triglyceridesMCPT, mouse mast cell proteaseMCT, medium chain triglyceridesMurine Models of Food AllergyOIT, oral immunotherapyPBMC, peripheral blood mononuclear cellSpontaneous SensitizationTSLP, thymic stromal lymphopoietinTh, T helperTreg, regulatory T cellWASP, Wiskott–Aldrich syndrome protein

More Related Videos

Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.5K
Studying Food Reward and Motivation in Humans
12:09

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

24.2K

Related Experiment Videos

Last Updated: Feb 5, 2026

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation
04:34

Mouse Body Temperature Measurement Using Infrared Thermometer During Passive Systemic Anaphylaxis and Food Allergy Evaluation

Published on: September 14, 2018

26.6K
Basophil Activation Test for Allergy Diagnosis
07:22

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

9.5K
Studying Food Reward and Motivation in Humans
12:09

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

24.2K

Area of Science:

  • Gastroenterology and Hepatology
  • Immunology
  • Allergy Research

Background:

  • Immunoglobulin E (IgE)-mediated food allergy is a significant and increasing global health concern.
  • Current treatments are limited to allergen avoidance and emergency interventions, highlighting the need for new therapeutic strategies.
  • Understanding food allergy pathophysiology is crucial for developing effective treatments, with mouse models being a primary research tool.

Purpose of the Study:

  • To review commonly used murine models of food allergy.
  • To discuss the relevance and limitations of these models in reflecting human food allergy.
  • To explore novel approaches like epicutaneous sensitization, spontaneous sensitization models, and humanized animal models.

Main Methods:

  • Review of existing literature on murine models of food allergy.
  • Focus on epicutaneous sensitization models.
  • Analysis of spontaneous sensitization models and humanized animal models.

Main Results:

  • Experimental models of food allergy present challenges due to discrepancies between mouse and human disease presentation.
  • Specific models discussed include epicutaneous sensitization, spontaneous sensitization, and humanized animal models.
  • These models aim to better mimic human food allergy for improved research translation.

Conclusions:

  • Developing a diverse range of experimental food allergy models is essential for advancing research.
  • These models are critical for understanding the immune mechanisms underlying human food allergy.
  • Expanding the research toolbox will facilitate the discovery of new therapeutic targets for food allergy treatment.