Related Experiment Video
Updated: Feb 5, 2026

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
Published on: February 21, 2018
Tuning the biomimetic performances of 4-hydroxyproline-containing cyclic peptoids
R Schettini1, C Costabile, G Della Sala
1Department of Chemistry and Biology "A. Zambelli", University of Salerno, Via Giovanni Paolo II, 132, Fisciano (SA) 84084, Italy. iizzo@unisa.it.
Abstract:
Five new cyclic peptoids containing (2S,4R)-4-hydroxyproline (Hyp) residues have been designed and synthesized using a mixed "submonomer/monomer" approach. Alkali metal cation affinities and ion transport activities were assessed by experimental (NMR and HPTS assay in liposomes) and computational methods. Easy functionalization of hydroxyproline residues afforded a bouquet of cyclic oligomers showing correlation between ion transport abilities and cytotoxic activities on selected human cancer cell lines.
Related Concept Videos
Stereoisomerism of Cyclic Compounds
Problem-Solving: Tuning of a Guitar String
The string's wave speed can be regulated by varying the linear density. Tension is the other property that determines the speed of...
Voltammetric Techniques: Cyclic Voltammetry
Cyclic Processes And Isolated Systems
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state.
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
Dipeptidyl Peptidase 4 Inhibitors
Amides to Amines: LiAlH4 Reduction
Amide reduction requires two equivalents of the reducing agent, acting as a source of hydride ions. As shown in the figure, the reaction is initiated with a nucleophilic attack by the hydride ion at the carbonyl carbon to form a tetrahedral intermediate.

