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Pacemaker-associated thrombosis in ongoing therapy with edoxaban tosylate
Angelo Di Vincenzo1, Alessandro Rizzo2, Lucia Russo3
1Internal Medicine 3, University Hospital of Padova, Via Giustiniani 2, 35128, Padua, Italy. divincenzoang@gmail.com.
Journal of Thrombosis and Thrombolysis
|September 6, 2018
Summary
Pacemaker implantation can cause thromboembolism, even with anticoagulant therapy. This case highlights that continuous edoxaban did not prevent pacemaker lead thrombosis, suggesting current prophylaxis strategies may be insufficient.
Area of Science:
- Cardiology
- Vascular Medicine
Background:
- Thromboembolism is a recognized complication following pacemaker implantation.
- Antithrombotic prophylaxis is not routinely used for preventing pacemaker lead-associated thrombosis.
Observation:
- A patient undergoing continuous oral anticoagulant therapy with edoxaban developed pacemaker lead-associated thrombosis.
- Existing literature lacks data on anticoagulant prophylaxis for pacemaker lead thrombosis.
Findings:
- Continuous edoxaban treatment was ineffective in preventing pacemaker lead thrombosis in this patient.
- Three-dimensional transthoracic echocardiography aided in the diagnostic assessment of thrombosis.
Implications:
- Current clinical practices for pacemaker implantation may require re-evaluation regarding thrombotic event prevention.
- Further research is needed to establish effective prophylactic strategies for pacemaker lead thrombosis, especially in patients on anticoagulation.
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