Related Experiment Video

Updated: Feb 5, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

847

Targeting the overexpressed USP7 inhibits esophageal squamous cell carcinoma cell growth by inducing NOXA-mediated

Tao Hu1, Jingyang Zhang1,2, Beibei Sha1

  • 1College of Basic Medical Sciences, Zhengzhou University; Collaborative Innovation Center of Henan province for cancer chemoprevention, Zhengzhou, China.

Molecular Carcinogenesis
|September 6, 2018
PubMed

Insights

Deubiquitinase USP7 is overexpressed in esophageal squamous cell carcinoma (ESCC). Targeting USP7 inhibits ESCC growth and induces apoptosis, suggesting its potential as a therapeutic target for ESCC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Deubiquitinase USP7 is implicated in various cancers.
  • Its role and therapeutic potential in esophageal cancer are largely unknown.
  • Esophageal squamous cell carcinoma (ESCC) is a significant global health concern.

Purpose of the Study:

  • To investigate the expression and function of USP7 in ESCC.
  • To evaluate the anti-cancer effects of targeting USP7 in ESCC.
  • To elucidate the underlying molecular mechanisms of USP7 inhibition in ESCC.

Main Methods:

  • Quantitative analysis of USP7 expression in ESCC tissues.
  • In vitro and in vivo studies using pharmaceutical or genetic USP7 inhibition.
  • Analysis of protein ubiquitination, endoplasmic reticulum stress markers, and apoptosis pathways.

Main Results:

  • USP7 was significantly overexpressed in ESCC tissues compared to adjacent normal tissues.
  • USP7 inhibition suppressed ESCC cell proliferation and induced apoptosis both in vitro and in vivo.
  • USP7 inhibition led to accumulation of poly-ubiquitinated proteins, ER stress, and ATF4 upregulation, ultimately activating NOXA-mediated apoptosis.

Conclusions:

  • USP7 is a promising therapeutic target for ESCC.
  • Targeting USP7 demonstrates significant anti-cancer effects in ESCC models.
  • Further clinical investigation of USP7 inhibitors for ESCC treatment is warranted.
Keywords:
NOXAP5091USP7apoptosisesophageal squamous cell carcinoma

More Related Videos

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids10:43

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

4.1K
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma06:11

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

Published on: April 20, 2018

10.3K

Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.1K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.6K
Apoptosis01:30

Apoptosis

Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
15.1K
Cells Coordinate Growth and Proliferation02:36

Cells Coordinate Growth and Proliferation

Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
5.1K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
84.1K
Target Cell Response to Hormones01:22

Target Cell Response to Hormones

Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
5.8K