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[Behavioural changes as a symptom: diagnosing behavioural variant frontotemporal dementia].
Everard G B Vijverberg1,2, Flora Gossink1, Welmoed Krudop3
1Amsterdam UMC, Alzheimer Centrum en afd. Neurologie, Amsterdam.
Nederlands Tijdschrift Voor Geneeskunde
|September 6, 2018
Summary
Behavioural variant frontotemporal dementia (bvFTD) is a neurodegenerative disease causing character and behavioral changes. Diagnosis relies on MRI, questionnaires, and neuropsychological tests, with a multidisciplinary approach recommended for suspected cases.
Area of Science:
- Neurology
- Neuroscience
- Geriatrics
Background:
- Behavioural variant frontotemporal dementia (bvFTD) presents with significant changes in personality, behavior, and social cognition, typically affecting individuals aged 40-70.
- Diagnostic challenges arise when characteristic frontotemporal atrophy is not evident on imaging, necessitating careful differentiation from psychiatric and other neurological disorders.
Purpose of the Study:
- To outline the diagnostic process for behavioural variant frontotemporal dementia (bvFTD).
- To highlight the utility of various diagnostic tools and recommend a management strategy for suspected bvFTD.
Main Methods:
- Review of diagnostic criteria and imaging findings for bvFTD.
- Evaluation of validated questionnaires for behavioral symptoms, depressive symptoms, and apathy.
- Assessment of neuropsychological examination and neuroimaging (MRI, 18F-FDG-PET) in diagnosis.
Main Results:
- Frontotemporal atrophy on MRI supports a diagnosis of probable bvFTD in 70% of cases.
- Questionnaires and neuropsychological tests aid in distinguishing bvFTD from other conditions.
- 18F-FDG-PET scans can be supplementary but may yield false positives.
Conclusions:
- A brain MRI is crucial for patients with behavioral changes suggestive of bvFTD.
- A multidisciplinary approach, extended clinical follow-up, and referral to specialized centers are recommended for managing suspected bvFTD.
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