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Sequence and evolution of rhesus monkey alphoid DNA.

L M Pike, A Carlisle, C Newell

Journal of Molecular Evolution

|January 1, 1986

Summary

Rhesus monkey alphoid DNA evolved through duplication and variation. Sequence changes in conserved regions, including protein binding sites, may influence centromere evolution in primates.

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Area of Science:

Genomics
Molecular Evolution
Primate Genetics

Background:

Alphoid DNA constitutes the primary centromeric satellite DNA in primates.
Understanding alphoid DNA evolution is crucial for deciphering centromere function and chromosome dynamics.

Purpose of the Study:

To analyze the evolutionary history and sequence characteristics of rhesus monkey alphoid DNA.
To investigate the conservation and variation within alphoid DNA monomers and dimers.

Main Methods:

DNA sequencing and comparative analysis of rhesus monkey alphoid DNA.
Identification of conserved regions and sequence variations within dimer units.

Main Results:

Rhesus monkey alphoid DNA originated from tandem duplication and subsequent variation of ancestral monomers.
The consensus dimer shows high homology to other cercopithecid alphoid DNAs but is less homologous to human sequences.
Conserved regions, including alpha-protein binding sites, exhibit unexpected sequence variations.

Conclusions:

Sequence variation within conserved regions of alphoid DNA may lead to unique nucleosomal structures.
These variations can influence the evolution of repetitive DNA and contribute to primate centromere characteristics.

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