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Touch-actuated microneedle array patch for closed-loop transdermal drug delivery.

Jingbo Yang1, Zhipeng Chen1, Rui Ye1

  • 1a Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering , Sun Yat-Sen University , Guangzhou , PR China.

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|September 6, 2018
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Summary
This summary is machine-generated.

A novel touch-actuated microneedle array patch (TMAP) enables effective transdermal delivery of macromolecular drugs. Insulin-loaded TMAP demonstrated superior glycemic control in diabetic rats, offering a promising alternative to injections.

Keywords:
Transdermal drug deliveryclosed-loop controldiabetesinsertioninsulinmicroneedle arraytraditional transdermal patch

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Area of Science:

  • Biomedical Engineering
  • Drug Delivery Systems
  • Materials Science

Background:

  • Traditional transdermal patches (TTP) are limited to small molecules due to poor skin permeation of macromolecules.
  • Developing effective transdermal delivery for macromolecular drugs remains a significant challenge.

Purpose of the Study:

  • To develop and evaluate a novel touch-actuated microneedle array patch (TMAP) for transdermal delivery of liquid macromolecular drugs.
  • To assess the efficacy of TMAP for insulin delivery in a type 1 diabetic rat model.

Main Methods:

  • TMAP combines a TTP with a solid microneedle array (MA) for enhanced skin penetration.
  • The patch utilizes a 'press and release' mechanism to create microchannels in the stratum corneum.
  • Insulin-loaded TMAPs were tested for hypoglycemic effects in type 1 diabetic rats, with comparisons to other delivery methods.

Main Results:

  • Insulin-loaded TMAP demonstrated the most effective hypoglycemic effect compared to subcutaneous injection, TTP, solid MA, and dissolvable MA.
  • A closed-loop system provided on-demand insulin delivery based on blood glucose levels (BGLs).
  • TMAP maintained normoglycemia in diabetic rats for approximately 11.63 hours, the longest duration reported for microneedle patches.

Conclusions:

  • TMAP offers a viable and effective platform for transdermal delivery of macromolecular drugs, including insulin.
  • The patch technology shows significant potential for improving glycemic control and therapeutic duration in diabetes management.
  • TMAP represents a breakthrough in transdermal drug delivery, overcoming limitations of conventional methods.