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Dynamical comparison between myoglobin and hemoglobin

Rotem Aharoni1, Dror Tobi1,2

  • 1Department of Molecular Biology, Ariel University, Ariel, Israel.

Proteins
|September 6, 2018
PubMed

Myoglobin and hemoglobin are globular hemeproteins, when the former is a monomer and the latter a heterotetramer. Despite the structural similarity of myoglobin to α and β subunits of hemoglobin, there is a functional difference between the two proteins, owing to the quaternary structure of hemoglobin. The effect of the quaternary structure of hemoglobin on the intrinsic dynamics of its subunits is explored by dynamical comparison of the two proteins. Anisotropic Network Model modes of motion were calculated for hemoglobin and myoglobin. Dynamical comparison between the proteins was performed using global and local Anisotropic Network Model mode alignment algorithms based on the algorithms of Smith-Waterman and Needleman-Wunsch for sequence comparison. The results indicate that the quaternary structure of hemoglobin substantially alters the intrinsic dynamics of its subunits, an effect that may contribute to the functional difference between the two proteins. Local dynamics similarity between the proteins is still observed at the major exit route of the ligand.

Keywords:
Gaussian network modelanisotropic network modelcomparative dynamicsglobal alignmentlocal alignmentnormal mode analysisnormal modes alignmentprotein dynamics

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