Related Experiment Video

Updated: Feb 5, 2026

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse
06:04

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

8.1K

Echocardiographic evaluation of diastolic dysfunction in young and healthy patients with psoriasis: A case-control

Elio Gorga1, Marta Scodro, Francesca Valentini

  • 1University of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health. elio.gorga@gmail.it.

Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace
|September 6, 2018
PubMed

Insights

Psoriasis patients often have preclinical cardiac dysfunction, specifically diastolic dysfunction and increased mitral regurgitation, even without traditional cardiovascular risk factors. Early detection in psoriasis can improve heart health outcomes.

Area of Science:

  • Cardiology
  • Dermatology
  • Systemic Inflammatory Diseases

Background:

  • Psoriasis is a prevalent systemic inflammatory disease.
  • Inappropriate immune activation in psoriasis is linked to cardiovascular risk.
  • Previous studies suggest higher cardiovascular disorder incidence and echocardiographic abnormalities in psoriatic patients.

Purpose of the Study:

  • To evaluate preclinical cardiac dysfunction in psoriasis patients without cardiovascular risk factors.
  • To compare echocardiographic findings between psoriasis patients and a healthy control group.

Main Methods:

  • A cohort of 52 chronic plaque psoriasis patients was compared to a control group.
  • Conventional echocardiography and tissue Doppler imaging (TDI) were performed on all participants.
  • Analysis focused on left and right ventricular function, dimensions, mass, and mitral regurgitation.

Main Results:

  • Left ventricular dimensions, mass, and systolic function were normal in psoriasis patients.
  • Left ventricular diastolic dysfunction was observed in 36.5% of psoriasis patients versus 0% in controls.
  • Psoriasis patients showed a reduced E/A ratio in the right ventricle and significantly increased mitral regurgitation.

Conclusions:

  • Psoriasis patients exhibit preclinical cardiac dysfunction, particularly diastolic dysfunction and mitral regurgitation, independent of traditional risk factors.
  • Early echocardiographic screening in psoriasis patients is crucial for timely intervention.
  • Identifying and treating subclinical cardiac issues may improve the cardiovascular prognosis of psoriasis patients.

Keywords:
Psoriasisatherosclerosiscardiovascular riskdiastolic disfunctionechocardiography.

More Related Videos

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

4.4K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

941

Related Concept Videos

Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
160
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
474
Nursing Process for Patient and Caregiver Teaching III: Evaluation and Documentation01:20

Nursing Process for Patient and Caregiver Teaching III: Evaluation and Documentation

Evaluation of the teaching process enables the nurse to determine if the patient's learning needs were met and if training was effective. If the expected outcomes are not met, the care plan is revised, and additional education or reinforcement is provided. Nurses can ask questions after the session or obtain feedback to assess the patient's understanding of the topic.
Nurses can use several methods to evaluate patient outcomes. For example, oral questions can assess cognitive learning,...
2.6K
Control System Problem01:21

Control System Problem

In an open-loop system, such as a basic thermostat, the poles of the transfer function influence the system's response but do not determine its stability. However, when feedback is introduced to form a closed-loop system, such as an advanced thermostat that adjusts heating based on room temperature, stability is governed by the new poles of the closed-loop transfer function.
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
437
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.7K
Control Systems01:10

Control Systems

Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
1.9K