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Updated: Jul 9, 2026
09:27
Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
Published on: January 5, 2016
Alpha-Synuclein Nitration and Its Implications in Parkinson's Disease
Yixi He1, Zhongwang Yu2, Shengdi Chen1
1Department of Neurology and Institute of Neurology , Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China.
ACS Chemical Neuroscience
|September 6, 2018
Summary
Nitrative stress modifies alpha-synuclein (α-synuclein) in Parkinson's disease, contributing to neurodegeneration. This review explores α-synuclein nitration and its pathological roles in Parkinson's disease.
Area of Science:
- Neuroscience
- Pathology
- Biochemistry
Background:
- Parkinson's disease involves dopaminergic neuron loss and Lewy body formation.
- Lewy bodies are mainly composed of alpha-synuclein (α-synuclein).
- Nitrative stress-induced post-translational modifications of α-synuclein are implicated in neurodegeneration.
Purpose of the Study:
- To review the concept of α-synuclein nitration.
- To discuss the biological consequences of α-synuclein nitration.
- To explore the pathological roles and clinical implications of nitrated α-synuclein in Parkinson's disease.
Main Methods:
- Literature review.
- Synthesis of existing research on α-synuclein modifications.
- Analysis of pathological mechanisms in Parkinson's disease.
Main Results:
- α-synuclein nitration is a key modification under nitrative stress.
- Nitrated α-synuclein exhibits distinct biological consequences.
- Evidence links nitrated α-synuclein to neurodegenerative processes in Parkinson's disease.
Conclusions:
- α-synuclein nitration is a significant factor in Parkinson's disease pathogenesis.
- Understanding nitrated α-synuclein offers potential therapeutic targets.
- Further research into nitrated α-synuclein could yield clinical insights for Parkinson's disease.
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