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Updated: Jul 9, 2026

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
Published on: January 5, 2016
Alpha-Synuclein Nitration and Its Implications in Parkinson's Disease
Yixi He1, Zhongwang Yu2, Shengdi Chen1
1Department of Neurology and Institute of Neurology , Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China.
Abstract:
Parkinson's disease is pathologically characterized by the degeneration of dopaminergic neurons in the substantia nigra and the accumulation of neuronal cytoplasmic inclusions known as Lewy bodies, which are primarily composed of α-synuclein. Post-translational modifications of α-synuclein induced by nitrative stress have been linked to neurodegeneration. Here, we review the concept of α-synuclein nitration and its biological consequences. We also discuss the pathological roles of nitrated α-synuclein and their potential clinical implications in Parkinson's disease.
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