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Predictive Value of Mean Platelet Volume in Saphenous Vein Graft Disease

Ugur Kaya1, Yavuzer Koza2

  • 1Department of Cardiovascular Surgery, Ataturk University, Faculty of Medicine, Erzurum, Turkey.

Brazilian Journal of Cardiovascular Surgery
|September 6, 2018
PubMed

Insights

Mean platelet volume (MPV) may predict saphenous vein graft disease and early death after coronary artery bypass graft (CABG) surgery. Higher MPV levels were associated with increased risk in patients undergoing CABG.

Area of Science:

  • Cardiology
  • Hematology
  • Surgical Outcomes

Background:

  • Coronary artery bypass graft (CABG) surgery is a critical intervention for coronary artery disease.
  • Assessing risk factors for mortality and graft patency post-CABG is crucial for patient management.
  • Platelet indices, including mean platelet volume (MPV), platelet distribution width (PDW), and platelet count, are increasingly recognized for their role in cardiovascular health.

Purpose of the Study:

  • To investigate the potential of MPV, PDW, and platelet count as predictors of mortality after CABG surgery.
  • To evaluate these platelet parameters as indicators of saphenous vein graft disease (SVGD) and patency post-CABG.

Main Methods:

  • Retrospective review of 128 patients undergoing coronary angiography after CABG.
  • Patients were categorized into early death, no SVGD, and SVGD groups.
  • MPV, PDW, and platelet count were analyzed at various time points pre- and post-surgery.

Main Results:

  • Significantly higher MPV in patients with SVGD compared to those without (9.7±1.8 fl vs. 8.2±0.9 fl, P<0.05).
  • Elevated postoperative MPV ratios observed in the SVGD group (9.6±1.8 fl vs. 7.8±0.9 fl, P<0.05).
  • Higher MPV values correlated with early mortality (9.4±1.9 fl vs. 8.0±1.0 fl, P<0.05); MPV > 7.9 predicted early death with 80% sensitivity.

Conclusions:

  • MPV demonstrates potential as a predictive marker for SVGD.
  • MPV may serve as a valuable indicator for predicting mortality risk following CABG surgery.
  • Platelet count and PDW did not show significant differences between early death and surviving groups.
Abstract

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