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Microcephaly in Colombia before the Zika outbreak: A systematic literature review

Estephania Candelo1, Gabriela Caicedo, Max Feinstein

  • 1Centro de Investigaciones en Anomalías Congénitas y Enfermedades Raras, Universidad Icesi, Cali, Colombia Biomaterials and Tissues Engineering, University College London, London, United Kingdom. ecandelo@icesi.edu.co.

Biomedica : Revista Del Instituto Nacional De Salud
|September 6, 2018
PubMed
Abstract

Insights

The prevalence of microcephaly in Colombia between 1982 and 2013 averaged 1.8 per 10,000 births. This baseline data is crucial for understanding potential changes following Zika virus (ZV) introduction.

Area of Science:

  • Pediatrics
  • Epidemiology
  • Virology

Background:

  • Microcephaly is a condition defined by a smaller than normal head circumference.
  • Recent evidence links Zika virus (ZV) infection to microcephaly cases.

Purpose of the Study:

  • To establish a baseline prevalence of microcephaly in Colombia prior to the Zika virus epidemic.
  • To provide data for comparison with post-epidemic prevalence rates.

Main Methods:

  • Systematic review of published literature and reports.
  • Searched databases including Medline, Scopus, Scielo, and Lilacs.
  • Included studies reporting microcephaly prevalence in Colombia between 1982 and 2013.

Main Results:

  • Reviewed 32 non-duplicate articles, selecting 12 for analysis.
  • Included data from a total of 2,808,308 births.
  • Identified a microcephaly prevalence ranging from 0.3 to 3.1 per 10,000 births.

Conclusions:

  • The average prevalence of microcephaly in Colombia before ZV was 1.8 per 10,000 births (95% CI 1.7-1.8).
  • This pre-epidemic data serves as a critical reference point.
  • Essential for assessing the impact of Zika virus on microcephaly rates in Colombia.
Keywords:
ColombiaMicrocephalyZika virus infectioncongenital abnormalitiesprevalence

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