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A comparison based digital waveform generator for high resolution duty cycle.

Nathan M Hoffman1, Zachary P Gotlib1, Bojana Opačić1

  • 1Department of Chemistry, Washington State University, Pullman, Washington 99164-4630, USA.

The Review of Scientific Instruments
|September 7, 2018
PubMed
Summary
This summary is machine-generated.

A novel digital waveform generator precisely controls duty cycles for digital mass filters. This innovation improves mass spectrometry by enabling precise control over quadrupole rod sets, demonstrated with lysozyme analysis.

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Area of Science:

  • Analytical Chemistry
  • Instrumentation
  • Mass Spectrometry

Background:

  • Digital mass filters require precise waveform control for accurate analysis.
  • Existing methods for generating control waveforms can be complex or lack fine-tuning capabilities.

Purpose of the Study:

  • To develop a new comparison-based digital waveform generator.
  • To enable purely duty cycle controlled digital mass filters.
  • To demonstrate improved duty cycle control for mass spectrometry.

Main Methods:

  • A waveform generator was designed using the comparison of a periodic waveform and a DC level.
  • The generator produces a digital waveform with controlled duty cycle.
  • The method was validated by analyzing electrosprayed lysozyme using a quadrupole rod set.

Main Results:

  • The developed generator directly enables purely duty cycle controlled digital mass filters.
  • Improved duty cycle control was achieved compared to conventional methods.
  • A mass spectrum of lysozyme was successfully generated by varying the duty cycle.

Conclusions:

  • The comparison-based digital waveform generator offers a direct and effective method for duty cycle control.
  • This approach enhances the performance of digital mass filters.
  • The use of an inexpensive open-source microcontroller facilitates practical implementation and control.