Related Experiment Video
Updated: Feb 5, 2026
05:02
Growth of Gold Dendritic Nanoforests on Titanium Nitride-coated Silicon Substrates
Published on: June 3, 2019
6.9K
Surface modification of titanium with hydroxyapatite layer induced by phase-transited lysozyme coating
Summary
A new green method, phase-transited lysozyme-assisted hydroxyapatite formation (PAH), coats titanium implants with hydroxyapatite (HAP). This biomimetic mineralization improves implant biocompatibility and bone growth, offering a promising alternative to traditional methods.
Area of Science:
- Biomaterials Science
- Surface Chemistry
- Biomedical Engineering
Background:
- Titanium implants require surface modification to enhance bioactivity.
- Traditional hydroxyapatite (HAP) coating methods are harsh, using strong chemicals or high temperatures.
- Developing milder, biomimetic coating techniques is crucial for implant development.
Purpose of the Study:
- To introduce a novel, green methodology for hydroxyapatite (HAP) coating on titanium.
- To investigate the mechanism of phase-transited lysozyme-assisted hydroxyapatite formation (PAH).
- To evaluate the biocompatibility and osteoinductivity of HAP-coated titanium.
Main Methods:
- Utilized phase-transited lysozyme (PTL) to facilitate biomimetic mineralization of HAP on titanium.
- Employed PTL's carboxyl groups for Ca2+ ion concentration and HAP nucleation.
- Coated titanium surfaces using simulated body fluid (SBF) for crystal growth.
- Conducted in vitro and in vivo experiments to assess surface properties.
Main Results:
- Successfully coated titanium with a HAP/PTL-Ti multilayer using the PAH method.
- Demonstrated improved biocompatibility of the modified titanium surface.
- Verified enhanced osteoinductivity of the HAP/PTL-Ti multilayer in vivo.
- PAH process confirmed as simple, rapid, low-cost, and green.
Conclusions:
- The PAH method provides an effective and environmentally friendly approach for HAP coating on titanium.
- HAP/PTL-Ti multilayer surfaces exhibit superior biocompatibility and osteoinductivity compared to pristine titanium.
- PAH is a promising technique for surface modification of titanium implants, enhancing osseointegration.
More Related Videos
Related Concept Videos
02:31Phase Transitions
23.2K
Whether solid, liquid, or gas, a substance's state depends on the order and arrangement of its particles (atoms, molecules, or ions). Particles in the solid pack closely together, generally in a pattern. The particles vibrate about their fixed positions but do not move or squeeze past their neighbors. In liquids, although the particles are closely spaced, they are randomly arranged. The position of the particles are not fixed—that is, they are free to move past their neighbors to...
23.2K
02:33Phase Transitions: Sublimation and Deposition
20.2K
Some solids can transition directly into the gaseous state, bypassing the liquid state, via a process known as sublimation. At room temperature and standard pressure, a piece of dry ice (solid CO2) sublimes, appearing to gradually disappear without ever forming any liquid. Snow and ice sublimate at temperatures below the melting point of water, a slow process that may be accelerated by winds and the reduced atmospheric pressures at high altitudes. When solid iodine is warmed, the solid sublimes...
20.2K
02:39Phase Transitions: Melting and Freezing
15.2K
Heating a crystalline solid increases the average energy of its atoms, molecules, or ions, and the solid gets hotter. At some point, the added energy becomes large enough to partially overcome the forces holding the molecules or ions of the solid in their fixed positions, and the solid begins the process of transitioning to the liquid state or melting. At this point, the temperature of the solid stops rising, despite the continual input of heat, and it remains constant until all of the solid is...
15.2K
02:39Phase Transitions: Vaporization and Condensation
21.5K
The physical form of a substance changes on changing its temperature. For example, raising the temperature of a liquid causes the liquid to vaporize (convert into vapor). The process is called vaporization—a surface phenomenon. Vaporization occurs when the thermal motion of the molecules overcome the intermolecular forces, and the molecules (at the surface) escape into the gaseous state. When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase molecules...
21.5K
02:39Phase Diagrams
50.3K
A phase diagram combines plots of pressure versus temperature for the liquid-gas, solid-liquid, and solid-gas phase-transition equilibria of a substance. These diagrams indicate the physical states that exist under specific conditions of pressure and temperature and also provide the pressure dependence of the phase-transition temperatures (melting points, sublimation points, boiling points). Regions or areas labeled solid, liquid, and gas represent single phases, while lines or curves represent...
50.3K
02:32Histone Modification
16.2K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.2K