Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is a Nervous System?01:25

What is a Nervous System?

105.1K
Overview
105.1K
The Parasympathetic Nervous System01:14

The Parasympathetic Nervous System

115.8K
Overview
115.8K
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

103.9K
Overview
103.9K
The Central Dogma01:25

The Central Dogma

139.9K
Overview
139.9K
The Central Dogma01:20

The Central Dogma

33.9K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
33.9K
Nervous System01:21

Nervous System

3.5K
The nervous system coordinates body functions through its complex network of nerve cells, enabling sensation and movement. It is divided into two primary parts: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord. The brain acts as the body's control center, processing sensory information and coordinating responses. The spinal cord functions as a major signaling pathway for the brain and the rest of the body.
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the Nutritional and Neurodevelopmental Status in Children Attending Preschools in a Neighborhood in Bogotá, Colombia.

Nutrients·2026
Same author

Characterisation of Ocular Manifestations in Patients with Multiple Sclerosis in Colombia: A Multicentric Study.

Neuro-ophthalmology (Aeolus Press)·2026
Same author

Test-retest repeatability of the multiple sleep latency test in non-cataleptic hypersomnolence disorders.

Sleep medicine·2026
Same author

High-risk Obstructive sleep apnea (OSA), insomnia, and comorbid OSA (COMISA) increase likelihood of poor functional status in neurological and psychiatric populations.

Sleep medicine·2025
Same author

Establishing the Relationship Between Attention Deficit Hyperactivity Disorder and Emotional Facial Expression Recognition Deficit: A Systematic Review.

Journal of attention disorders·2023
Same author

Experience of Subcutaneous Levetiracetam in Palliative Care.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre·2023

Related Experiment Video

Updated: Feb 5, 2026

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
14:55

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

Published on: May 12, 2013

61.9K

Leptin: role over central nervous system in epilepsy.

Laura Mora-Muñoz1, Alejandro Guerrero-Naranjo1, Elisa Angélica Rodríguez-Jimenez1

  • 1Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Cra 24 No 63C-69, Bogotá, Colombia.

BMC Neuroscience
|September 7, 2018
PubMed
Summary

Leptin, a hormone regulating metabolism, influences brain function and neuronal excitation. Studies suggest leptin has both anticonvulsant and convulsant effects, indicating potential therapeutic roles in epilepsy treatment.

Keywords:
Adipose tissueAnticonvulsantsConvulsantsEpilepsyHypothalamusLeptinNervous system

More Related Videos

Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

28.9K
Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
10:28

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

14.1K

Related Experiment Videos

Last Updated: Feb 5, 2026

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
14:55

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

Published on: May 12, 2013

61.9K
Culturing Microglia from the Neonatal and Adult Central Nervous System
11:28

Culturing Microglia from the Neonatal and Adult Central Nervous System

Published on: August 9, 2013

28.9K
Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY
10:28

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

14.1K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Metabolic research

Background:

  • Adipose tissue is a dynamic endocrine organ.
  • Leptin, a key hormone from adipose tissue, regulates feeding and energy metabolism.
  • Leptin also modulates neuronal excitatory activity and higher brain functions.

Purpose of the Study:

  • To review the association between leptin and cerebral neuronal function.
  • To investigate leptin's anticonvulsant and convulsant effects.
  • To explore leptin's potential therapeutic role in epilepsy.

Main Methods:

  • Searched PubMed, Science Direct, Elsevier, ResearchGate, and SciELO.
  • Included experimental studies, reviews, and systematic reviews.
  • Focused on articles in English, Spanish, or Portuguese.

Main Results:

  • Experimental studies and leptin receptors outside the hypothalamus suggest leptin influences higher brain functions.
  • Animal studies show leptin affects epileptiform activity, with both anticonvulsant and convulsive effects observed.
  • The exact reasons for these dual effects remain unclear.

Conclusions:

  • Leptin plays a role in regulating brain excitatory activity.
  • Leptin's influence on epileptiform activity suggests potential therapeutic applications for epilepsy.
  • Further research is needed to elucidate leptin's complex actions on central nervous system excitation.