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Computational modelling suggests complex interactions between interstitial flow and tumour angiogenesis.

Guillermo Vilanova1, Miguel Burés2, Ignasi Colominas3

  • 1Laboratori de Càlcul Numèric, Universitat Politècnica de Catalunya, Campus Nord, 08034 Barcelona, Spain guillermo.vilanova@upc.edu.

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Tumour angiogenic factors (TAFs) drive cancer growth by promoting new blood vessel formation. Interstitial fluid flow significantly alters this process, influencing tumour vascularization and potentially increasing malignancy.

Keywords:
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Area of Science:

  • Oncology
  • Biophysics
  • Mathematical Biology

Background:

  • Angiogenesis is crucial for tumor progression, supplying nutrients and oxygen via new blood vessels.
  • Tumor angiogenic factors (TAFs) in the extracellular matrix (ECM) stimulate angiogenesis.
  • Interstitial fluid flow in the ECM can influence TAF distribution and tumor vascularization.

Purpose of the Study:

  • To investigate the influence of interstitial fluid flow on tumor angiogenesis.
  • To develop a hybrid mathematical model simulating time-evolving capillary networks influenced by fluid dynamics.

Main Methods:

  • A hybrid mathematical model coupling fluid flow and angiogenesis was developed.
  • The model incorporates endothelial cells, filopodia, capillaries, and TAFs.
  • TAF transport considered both diffusion and convective transport by interstitial flow.

Main Results:

  • Simulations revealed significant alterations in newly formed vascular networks.
  • Capillary networks predominantly grew against the direction of interstitial fluid flow.
  • Interstitial flow impacts TAF distribution and subsequent angiogenesis.

Conclusions:

  • Interstitial fluid flow plays a critical role in shaping tumor vascular architecture.
  • Altered vascularization due to fluid flow may enhance tumor malignancy.
  • Findings suggest potential implications for cancer treatment strategies.