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Polygenic risk score for predicting weight loss after bariatric surgery.
Juan de Toro-Martín1,2, Frédéric Guénard1,2, André Tchernof2,3
1Institute of Nutrition and Functional Foods (INAF) and.
JCI Insight
|September 7, 2018
Summary
Genetic factors significantly influence weight loss after bariatric surgery. Incorporating polygenic risk scores improves prediction accuracy and cost-effectiveness, suggesting potential for presurgical genetic testing in severe obesity management.
Area of Science:
- Genetics
- Bariatric Surgery
- Obesity Medicine
Background:
- Weight loss variability after bariatric surgery is significant.
- Genetic background's contribution to this variability is not fully understood.
Purpose of the Study:
- To investigate the impact of genetic background on weight loss after biliopancreatic diversion with duodenal switch.
- To assess the utility of polygenic risk scores in predicting weight loss outcomes.
Main Methods:
- Monitored % excess body weight loss (%EBWL) in 865 patients over 48 months.
- Constructed two polygenic risk scores (PRS186 and PRS11) using SNPs associated with BMI.
Main Results:
- Including PRS186 significantly improved the prediction model's accuracy (ΔAUCadj = 0.021).
- Both PRS186 and PRS11 improved the overall model fit and reduced false negatives.
- PRS186 and PRS11 showed significant interactions with postsurgery time.
Conclusions:
- Genetic background significantly impacts weight loss following biliopancreatic diversion with duodenal switch.
- Polygenic risk scores enhance prediction accuracy and cost-effectiveness, supporting their use in presurgical assessment for severe obesity.
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