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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
804
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

541
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
541
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

632
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Related Experiment Video

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Small Bowel Transplantation In Mice
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Small Bowel Adenocarcinoma.

Emerson Y Chen1, Gina M Vaccaro1

  • 1Division of Hematology and Medical Oncology, Department of Medicine, Knight Cancer Institute, Oregon Health & Sciences University, Portland, Oregon.

Clinics in Colon and Rectal Surgery
|September 7, 2018
PubMed
Summary
This summary is machine-generated.

Small bowel adenocarcinoma, a distinct gastrointestinal cancer, requires more research for effective management. Current treatments are generalized, and early diagnosis is often missed, necessitating novel molecular studies and clinical trials.

Keywords:
small bowel adenocarcinomasmall bowel cancersmall bowel malignanciessmall intestinal adenocarcinomasmall intestinal cancer

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Area of Science:

  • Gastroenterology and Oncology
  • Cancer Biology

Background:

  • Small bowel adenocarcinoma is a distinct gastrointestinal cancer lacking prospective management data.
  • High-risk groups include patients with inflammatory bowel disease and inherited polyposis syndromes.
  • Delayed diagnosis due to lack of surveillance leads to advanced stage presentation.

Purpose of the Study:

  • To highlight the need for improved management strategies for small bowel adenocarcinoma.
  • To emphasize the necessity of understanding the unique molecular characteristics of this cancer.
  • To advocate for the development of targeted clinical trials.

Main Methods:

  • Review of current treatment considerations and management gaps.
  • Analysis of risk factors and diagnostic challenges.
  • Identification of research needs for molecular characterization.

Main Results:

  • Small bowel adenocarcinoma management is often extrapolated from other cancers.
  • Effective surveillance programs are lacking, leading to late-stage diagnosis.
  • Surgical resection remains the only curative option.

Conclusions:

  • Further research into the molecular differences of small bowel adenocarcinoma is crucial.
  • Improved prognostication and rational clinical trial design are needed.
  • Enhanced understanding will improve patient outcomes for this rare cancer.