Related Experiment Video

Updated: Feb 5, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K

Association Between BRCA Status and Triple-Negative Breast Cancer: A Meta-Analysis

Haixia Chen1, Jianming Wu1, Zhihong Zhang2

  • 1Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, China.

Frontiers in Pharmacology
|September 7, 2018
PubMed

Insights

BRCA1 gene mutations significantly increase the risk of triple-negative breast cancer (TNBC) and larger tumor burdens. This finding highlights the importance of BRCA status in aggressive breast cancer subtypes.

Area of Science:

  • Oncology
  • Genetics
  • Cancer Research

Background:

  • Triple-negative breast cancer (TNBC) is an aggressive subtype lacking key receptor expression.
  • BRCA genes are crucial tumor suppressors involved in DNA repair.
  • BRCA mutations can elevate breast and ovarian cancer risks due to impaired DNA repair.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the association between BRCA gene status and triple-negative breast cancer.
  • To investigate the link between BRCA1/BRCA2 mutations and TNBC risk.
  • To explore correlations between BRCA status, TNBC, and tumor characteristics.

Main Methods:

  • Systematic literature search of MEDLINE, Embase, and Cochrane Library (1959-2017).
  • Meta-analysis of 16 studies involving 46,870 breast cancer patients.
  • Calculation of odds ratios (OR) with 95% confidence intervals (CI) using fixed-effect and random-effect models.

Main Results:

  • BRCA1 mutation carriers showed a significantly higher likelihood of TNBC compared to BRCA2 carriers (OR: 3.292) and non-carriers (OR: 8.889).
  • High nuclear grade and larger tumor size (>2 cm) were more prevalent in BRCA1 carriers versus BRCA2 carriers and non-carriers.
  • The data indicate a strong association between BRCA1 mutations and aggressive TNBC phenotypes.

Conclusions:

  • BRCA1 mutation carriers have a substantially increased risk of developing triple-negative breast cancer.
  • BRCA1 mutations are linked to more aggressive tumor features, including high nuclear grade and larger tumor burden.
  • This meta-analysis underscores the importance of assessing BRCA status in TNBC patients for risk stratification and potential therapeutic strategies.
Keywords:
BRCA1BRCA2Triple-negative breast cancer (TNBC)meta-analysismutation

More Related Videos

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.6K
Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography10:10

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

Published on: July 29, 2011

15.7K

Related Concept Videos

Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
Cancer Survival Analysis01:21

Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
768
Scalar and Vector Triple Products01:06

Scalar and Vector Triple Products

Two vectors can be multiplied using a scalar product or a vector product. The resultant of a scalar product is scalar, while with vector products, the resultant is a vector. These rules of the scalar or vector product between two vectors can be applied to multiple vectors to obtain meaningful combinations. The scalar triple product is the dot product of a vector with the cross product of two vectors.
The scalar triple product is the dot product of a vector with the cross product of two vectors....
4.5K
Association Areas of the Cortex01:21

Association Areas of the Cortex

Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.4K
Associative Learning01:27

Associative Learning

Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
1.3K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
38.5K