Related Experiment Video

Updated: Feb 5, 2026

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis
09:36

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

686

Effect of Carotid Artery Morphological Variations on Cognitive Function

Lin Chen1, Jialu Huang1, Suxia Wang1,2

  • 1Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

Behavioural Neurology
|September 7, 2018
PubMed

Insights

Carotid artery variations (CAMV) can impact cognition. The K-type CAMV was linked to cognitive impairment, with MoCA tests being more effective than MMSE for detection.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Medical Imaging

Background:

  • Carotid artery morphological variations (CAMV) are common findings in medical imaging.
  • The impact of CAMV on cognitive function remains largely unexplored.

Purpose of the Study:

  • To investigate the potential causal relationship between CAMV and cognitive impairment.
  • To determine if specific CAMV types are associated with cognitive deficits.

Main Methods:

  • 96 hospitalized patients undergoing digital subtract angiography (DSA) were categorized into non-CAMV, T-type, and K-type groups.
  • Cognitive function was assessed using the Mini-Mental State Scale (MMSE), Montreal Cognitive Assessment (MoCA), Verbal Fluency Test (VFT), and Digital Span Test (DST).

Main Results:

  • The K-type CAMV group showed significantly higher positive rates on MoCA compared to non-CAMV and T-type groups (p < 0.001).
  • VFT and DST scores were significantly lower in the K-type CAMV group than in the non-CAMV and T-type groups (p < 0.001).
  • No significant differences in MMSE positive rates were observed among the non-CAMV, T-type, and K-type groups (p = 0.836).

Conclusions:

  • K-type CAMV is associated with cognitive impairment.
  • The Montreal Cognitive Assessment (MoCA) is more sensitive than the Mini-Mental State Scale (MMSE) for detecting mild cognitive impairment related to CAMV.
Abstract

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