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Prosthetic Joint Infection from Carbapenemase-Resistant Klebsiella pneumoniae Successfully Treated with

A Schimmenti1, E Brunetti1,2, E Seminari2

  • 1Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Unità di Malattie Infettive e Tropicali ed Epatologia, Università di Pavia, Pavia, Italy.

Case Reports in Infectious Diseases
|September 7, 2018
PubMed

Insights

Antimicrobial resistance is a major health threat. This study reports the first successful treatment of a prosthetic joint infection caused by carbapenemase-resistant Klebsiella pneumoniae using ceftazidime-avibactam.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Antimicrobial resistance in Gram-negative bacteria, especially Enterobacteriaceae, is a significant global health issue.
  • Extended-spectrum beta-lactamase (ESBL) and carbapenemase-producing bacteria are increasingly prevalent, leading to multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) infections.
  • Prosthetic joint infections (PJIs) pose a serious challenge due to limited treatment options for resistant pathogens.

Observation:

  • A patient in Italy presented with a prosthetic joint infection.
  • The infection was caused by carbapenemase-resistant Klebsiella pneumoniae (CRKP), a highly resistant Gram-negative bacterium.
  • Standard treatment options were likely limited due to the resistance profile.

Findings:

  • The patient with CRKP prosthetic joint infection was successfully treated with ceftazidime-avibactam.
  • This represents a novel therapeutic approach for this challenging infection.
  • Ceftazidime-avibactam demonstrated efficacy against a carbapenemase-resistant Gram-negative pathogen in a PJI setting.

Implications:

  • Ceftazidime-avibactam offers a potential treatment option for prosthetic joint infections caused by carbapenemase-resistant Gram-negative bacteria.
  • This case highlights the importance of novel antimicrobial agents in combating rising antimicrobial resistance.
  • Further research is warranted to evaluate the broader efficacy and safety of ceftazidime-avibactam in similar complex infections.

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