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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Published on: February 16, 2015
Principles of adoptive T cell therapy in cancer
Özcan Met1,2,3, Kasper Mølgaard Jensen4, Christopher Aled Chamberlain4
1Center for Cancer Immune Therapy, Department of Hematology, Copenhagen University Hospital, Entrance 81, Floor 05, 2730, Herlev, Denmark. ozcan.met@regionh.dk.
Abstract:
Adoptive cell therapy (ACT) utilizing either tumor-infiltrating lymphocyte (TIL)-derived T cells or T cells genetically engineered to express tumor recognizing receptors has emerged as a powerful and potentially curative therapy for several cancers. Many ACT-based therapies have recently entered late-phase clinical testing, with several T cell therapies already achieving regulatory approval for the treatment of patients with B cell malignancies. In this review, we briefly outline the principles of adoptively transferred T cells for the treatment of cancer.
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