Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

REM sleep deprivation induces a decrease in norepinephrine-stimulated 3H-cyclic AMP accumulation in slices from rat

L R Troncone, S Braz, M A Benedito

    Pharmacology, Biochemistry, and Behavior
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genetic factors underlying insomnia and ovarian insufficiency.

    Climacteric : the journal of the International Menopause Society·2023
    Same author

    Sleep bruxism and its associations with insomnia and OSA in the general population of Sao Paulo.

    Sleep medicine·2020
    Same author

    We never speak about sudden unexpected death in Parkinson's disease.

    European journal of neurology·2020
    Same author

    Sleep disturbances and residual neuromuscular blockade: future research possibilities.

    Anaesthesia·2020
    Same author

    Sleep disturbance and atopic dermatitis: A bidirectional relationship?

    Medical hypotheses·2020
    Same author

    Alopecia areata and sleep quality: is there an interaction?

    Journal of the European Academy of Dermatology and Venereology : JEADV·2019
    Same journal

    Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

    Pharmacology, biochemistry, and behavior·2026
    Same journal

    Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

    Pharmacology, biochemistry, and behavior·2026
    See all related articles

    REM sleep deprivation (REMSd) in rats reduces beta-adrenergic sites in the brain, similar to antidepressants. This study found REMSd decreases cyclic AMP production in response to norepinephrine, supporting receptor down-regulation and offering insights into depression management.

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Sleep Science

    Background:

    • Repeated antidepressant treatment down-regulates beta-adrenergic receptors in the rat brain.
    • REM sleep deprivation (REMSd) has been shown to produce similar effects on beta-adrenergic sites.

    Purpose of the Study:

    • To investigate the impact of REM sleep deprivation (REMSd) on the production of cyclic AMP in rat frontal cortical slices.
    • To examine the relationship between REMSd, adrenergic receptor function, and potential interactions with dopaminergic systems.

    Main Methods:

    • Rat frontal cortical slices were utilized.
    • Norepinephrine (NE) challenge was employed to stimulate cyclic AMP production.
    • The synthesis of 3H-cyclic AMP was measured following REM sleep deprivation.

    Related Experiment Videos

    Main Results:

    • REM sleep deprivation (REMSd) led to a significant decrease in 3H-cyclic AMP synthesis.
    • This finding is consistent with previous observations of adrenergic receptor down-regulation after REMSd.
    • The results suggest a functional consequence of receptor changes induced by sleep deprivation.

    Conclusions:

    • REM sleep deprivation (REMSd) impairs the cyclic AMP response to norepinephrine in the rat frontal cortex.
    • The findings support the hypothesis of adrenergic receptor down-regulation following REMSd.
    • Further research into the interaction with dopaminergic systems may offer new avenues for depression management.