Cannabidiol-caused depression of spinal motoneuron responses in cats

Intracellular recording techniques were used on spinal motoneurons in the cat in order to define the synaptic pharmacology of cannabidiol (CBD). The cannabinoid produces only depression of electrophysiological responses of the motoneurons: For instance, the drug decreases the amplitude of excitatory postsynaptic potentials (EPSPs); this reduction does not appear to be the result of a change in the afferent input. In addition, CBD raises the firing threshold and decreases the amplitude of motoneuron action potentials; the effects on action potentials are related to changes in postsynaptic membrane conductances, probably involving at least sodium conductance. The spinal motoneuron effects provide potential electrophysiological mechanisms for CBD's central depressant actions.