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Updated: Feb 5, 2026

Forming Giant-sized Polymersomes Using Gel-assisted Rehydration
Published on: May 26, 2016
Photo-crosslinked and esterase-sensitive polymersome for improved antitumor effect of water-soluble chemotherapeutics
1College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China.
Aim:
To meet the requirements on both delivery stability during blood circulation and fast intracellular release for water-soluble chemotherapeutics encapsulated in polymersomes.
Materials & Methods:
A shell photo-crosslinked and esterase-sensitive polymersome (C-PEAMP-D) was constructed based on amphiphilic polyphosphazene PEAMP containing 2-aminoethyl methacrylate.
Results:
The leakage of doxorubicin hydrochloride (DOX·HCl) was significantly inhibited from 42.27 to 26.64% in 10 h and the accelerated intracellular DOX·HCl release occurred responsively to the esterase at high concentration in cancer cells. Consequently, C-PEAMP-D achieved better antitumor efficiency when compared with free DOX·HCl and uncrosslinked PEAMP vesicle.
Conclusion:
We provided a strategy to conquer drug leakage in systemic circulation and trigger enzyme-sensitive drug release inside cancer cells for improving oncotherapy outcome of water-soluble chemotherapeutics.
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