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mRNA Polyplexes with Post-Conjugated GALA Peptides Efficiently Target, Transfect, and Activate Antigen Presenting

Bo Lou1, Stefaan De Koker2, Chun Yin Jerry Lau1

  • 1Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS) , Utrecht University , 3584CG Utrecht , The Netherlands.

Bioconjugate Chemistry
|September 7, 2018
PubMed
Summary

Researchers developed peptide-functionalized mRNA polyplexes (PPx-GALA) for efficient delivery into antigen-presenting cells (APCs). This novel mRNA vaccine platform enhances T cell responses and DC maturation, showing promise for in vivo applications.

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