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An In Vivo Murine Sciatic Nerve Model of Perineural Invasion

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Published on: April 23, 2018

Radiotherapy for Melanoma with Perineural Invasion: University of Florida Experience

Simeng Zhu¹, William M Mendenhall¹

¹a Department of Radiation Oncology , University of Florida College of Medicine , Gainesville , FL , USA.

Cancer Investigation

|September 7, 2018

Abstract

Purpose:

Outcomes after adjuvant radiotherapy for cutaneous melanoma with perineural invasion (PNI).

Methods:

Seven patients (5 cutaneous, 2 recurrent nerve lesions) received radiotherapy.

Results:

At a median 4.5 years: Two patients did not recur; no local failures occurred. Three patients who omitted nodal irradiation developed regional failures (2 out-of-field, 1 in-field). Three patients developed distant metastases. Four died with disease (median, 3.6 years); 1 died from intercurrent disease (13.0 years). Two are alive without disease (6.8 and 11.6 years). No patient experienced grade ≥3 toxicity.

Conclusions:

Postoperative radiotherapy can reduce local recurrences; primary radiotherapy for unresectable disease is recommended.

Keywords:

Radiation oncology cutaneous melanoma perineural invasion

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The Chick Chorioallantoic Membrane In Vivo Model to Assess Perineural Invasion in Head and Neck Cancer

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