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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Landiolol for rate control management of atrial fibrillation in patients with cardiac dysfunction

Stephan von Haehling1, Jan Bělohlávek2, Fikret Er3

  • 1Department of Cardiology and Pneumology, University of Göttingen Medical Center, Robert-Koch-Strasse 40, Göttingen, Germany.

European Heart Journal Supplements : Journal of the European Society of Cardiology
|September 7, 2018
PubMed

Insights

Landiolol, an ultra-short-acting beta-blocker, offers a new option for controlling heart rate in patients with atrial fibrillation and heart failure. This review explores its use for acute rate control in cardiac dysfunction.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Atrial fibrillation (AFib) commonly co-occurs with heart failure, complicating patient management.
  • Recent guideline updates emphasize tailored acute heart rate control strategies based on hemodynamic status and left ventricular ejection fraction.

Purpose of the Study:

  • To review existing clinical data on landiolol use in Japan for AFib rate control.
  • To discuss the perspectives of using landiolol for acute rate control in European patients with AFib and cardiac dysfunction.

Main Methods:

  • Review of published clinical data from Japan concerning landiolol's efficacy and safety.
  • Analysis of landiolol's pharmacological properties (ultra-short-acting, beta-1 selectivity) in the context of heart failure.

Main Results:

  • Landiolol is recognized in Japanese guidelines as a potential option for heart rate control in AFib patients with heart failure.
  • Landiolol is now approved in Europe for heart rate control in AFib and supraventricular tachycardia.

Conclusions:

  • Landiolol presents a promising therapeutic option for acute rate control in AFib patients experiencing cardiac dysfunction.
  • Further clinical data and real-world evidence will elucidate landiolol's role in managing AFib with heart failure in Europe.

Keywords:
Atrial fibrillationBeta-blockersHeart failureLandiololSupraventricular tachycardia

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